Testosterone Implants, Benefits and Myths

Introduction ^[1][2]
-Testosterone is a hormone found in humans, as well as in other animals.
-The testicles primarily make testosterone in men and most often associated with sex drive, it also plays a vital role in sperm production, Women’s ovaries also make testosterone, though in much smaller amounts.
-Testosterone production starts to increase significantly during puberty, and begins to dip after age 30.
-It can boost libido, increase muscle mass, sharpen memory, and bump up energy. Yet, most men lose testosterone with age.
“A reported 20 to 40 percent of older men have a medical condition called hypogonadism and need testosterone replacement therapy (TRT).”
-Successful hormone therapy involves getting just the right dose by the right delivery method for your individual needs, there are patches, creams, injections, and testosterone pellets.
-For delivering a consistent dose on the long term, pellets may be a good option.

Low Testosterone levels
Low levels of testosterone can produce a variety of symptoms in men, including:

• Decreased sex drive
• Less energy
• Weight gain
• Feelings of depression
• Moodiness
• Low self-esteem
• Less body hair
• Thinner bones

Testosterone pellets and procedure
-Testosterone pellets, such as Testopel, are small and measure 3 millimeters (mm) by 9 mm and contain crystalline testosterone.
-It is slowly release testosterone over the course of three to six months.
-Implantation is a simple procedure that typically takes only 10 minutes.
-The skin of the upper hip or buttocks is thoroughly cleaned then injected with a local anesthetic to reduce discomfort.
-A small incision is made. Tiny testosterone pellets are placed under the skin with an instrument called a trocar.
-Typically, 10 to 12 pellets are implanted during the procedure.
-These pellets are a long-acting form of testosterone therapy.
-They should deliver a stable, steady dose of testosterone, typically providing the needed level of hormone for four months.

Benefits of testosterone implants ^[3][4][5][6]

• For delivering a consistent dose over the long term, pellets are the best option. Pellets deliver consistent, physiologic levels of hormones and avoid the fluctuations of hormone levels seen with other methods of delivery.
• Extrusion and implantation infection rates at high-volume centers with Testopel® (approved by the FDA) are less than 1 %, and patient acceptance of the procedure is very high.
• None of the patients who complied with post-implant procedure instructions experienced infection or pellet extrusion.
• Patient satisfaction was high and serum hormone values were improved.
• Absence of foreign material within the pellet packaging.
• Implanted testosterone pellets can normalize testosterone and LH levels and improve symptoms for at least 3 months and up to 6 months in men with hypogonadism, and should be considered as a therapeutic option for hypogonadal men.
• Increase muscle mass, bump up energy, relieve depression, increase sense of well-being, relieve anxiety, improve memory
• Increase lean body mass (muscle strength, bone density) and decrease fat mass.
• Hormone replacement therapy with testosterone implants is superior to oral and topical (both the patch and gel) hormone replacement therapy for bone density.

Relationship between Testosterone therapy and prostate cancer?
There is no relationship.

Study (1)
“The relationship between testosterone and prostate cancer remains complex. While most studies suggest no relationship between testosterone supplementation and prostate cancer incidence and progression, most published studies are reassuring, with most of the discrepancy likely due to methodologic and patient heterogeneity. Current professional society guidelines for testosterone supplementation provide appropriate recommendations for proper patient treatment and monitoring” ^[7]

Study (2)
“Among men with low testosterone levels and normal PSA, testosterone treatment was not associated with an increased risk of aggressive or any prostate cancer (CaP). The clinical risks and benefits of testosterone treatment can only be fully addressed by large, longer-term randomized controlled trials.” ^[8]

Study (3)
“Despite the historical reluctance towards use of testosterone therapy in men with a history of prostate cancer, modern evidence suggests that testosterone replacement is a safe and effective treatment option for hypogonadal men with non-high-risk prostate cancer.” ^[9]

Study (4)
“The authors concluded that men with prostatic intraepithelial neoplasia (PIN) do not have an increased risk of cancer development when treated with testosterone replacement than men without PIN” ^[10]

Relationship between testosterone therapy and mortality risk?
There is no relationship.

Study (1)
“There appears to be no change in mortality risk overall for men utilizing long-term testosterone therapy.” ^[11]
The relationship between testosterone therapy and CV Risk
There is no relationship.

Study (1)
“There is no consistent evidence of increased cardiovascular risk with testosterone products” ^[12]

Study (2)
“Similar conclusions were reached as a joint consensus between the American Association of Clinical Endocrinologists and the American College of Endocrinology in an official position paper that essentially reports that no compelling evidence indicates that T therapy increases CV risk” ^[13]

Reference: –

• Medically reviewed by University of Illinois-Chicago, College of Medicine on August 26, 2016 — Written by James Roland https://www.healthline.com/health/what-is-testosterone
• Medically reviewed by Daniel Murrell, MD on August 24, 2018 — Written by Christine Case-Lo https://www.healthline.com/health/testosterone-pellets#talk-to-your-doctor
• A Review of Testosterone Pellets in the Treatment of Hypogonadism Andrew McCullough 2014 Oct 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431706/
• Cavender RK, Fairall M. Subcutaneous testosterone pellet implant (Testopel) therapy for men with testosterone deficiency syndrome: a single-site retrospective safety analysis. J Sex Med. 2009;6(11):3177-92. https://www.ncbi.nlm.nih.gov/pubmed/19796052
• Kaminetsky JC, Moclair B, Hemani M, Sand M. A phase IV prospective evaluation of the safety and efficacy of extended release testosterone pellets for the treatment of male hypogonadism. J Sex Med. 2011;8(4):1186-96. https://www.ncbi.nlm.nih.gov/pubmed/21269402
• Testosterone Pellet Therapy for Men by Paul Savage, MD, FAARM, ABAARM August 29, 2016 https://www.power2practice.com/article/male-testosterone-pellet-therapy/
• Testosterone Replacement Therapy and Prostate Cancer Incidence Michael Louis Eisenberg World J Mens Health. 2015 Dec; 33 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709428/
• Testosterone treatment and the risk of aggressive prostate cancer in men with low testosterone levels PLoS One. 2018; 13 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014638/
• Testosterone Therapy Among Prostate Cancer Survivors Sex Med Rev. Author manuscript; 2017 Oct 1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026903/
• Testosterone replacement therapy and the risk of prostate cancer Asian J Androl 2015 Apr 10 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814970/
• Testosterone Therapy and Mortality Risk Int J Impot Res 2014 Jul 31 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312542/
• Hackett GI. Testosterone Replacement Therapy and Mortality in Older Men. Drug Saf. 2016;39(2):117-30. https://www.ncbi.nlm.nih.gov/pubmed/26482385
• Testosterone Replacement Therapy and Cardiovascular Risk: A Review World J Mens Health 2015 Dec 23 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709429/

Buy Medicines From Wholesale Pharmaceutical Suppliers In UK

The pharmaceutical industry is a commercial industry that deals with medicines. The essential sector is involved in the discovery, development, manufacture and marketing of drugs. These drugs are beneficial for various treatments all over the world. Pharmaceutical companies operate under strict laws. These laws address issues including safety, efficiency, drug testing, patenting process etc. Wholesale pharmaceutical suppliers in UK serve clients in a dedicated manner and cater to their needs effectively.

Thousands of professionals are involved in the pharmaceutical industry spread all over the United Kingdom. The huge industry contributes significantly to the gross domestic product of the nation. Pharmaceutical products constitute a sizeable portion of the total exports of this country. In addition, the United Kingdom invests a huge amount in various researches related to the industry. The country stands at the third position in this aspect. It is also the prominent European country where most innovative discoveries happen.

Several big names had emerged from the country in the past. GlaxoSmithKline, the pharmaceutical giant is a British company. The company’s vaccines are top earners in the world. International companies also have obvious presence in the country’s drug market. The industry is very strong in London. The city is well-known for its role in revolutionary and innovative researches and inventions. It is true in the case of pharmaceutical industry too. A major portion of modern world’s popular medicines are manufactured in the country.

A brief look at the pharmaceutical industry in UK

The industry became a flourishing sector in the nineteenth century. It is considered as the main industry that contributes to the economy of the country. Steady rises in demand and massive revenue generation have been witnessed in the past decade. This upward trend is predicted to rise further in the years to come. This prediction is regarded as accurate by experts. The huge annual revenues achieved by the industry in recent years point to the direction.

Cambridge, Oxford and London are the country’s pharmaceutical hubs. A large portion of job opportunities in the sector is concentrated in London alone. In addition, the city provides jobs in the field throughout the nation. Any person who wishes to work in the industry travels to the city. Most popular careers are in the research and manufacturing sectors, along with sales domain and managerial ones. The industry also provides satisfying careers with high salary packages.

Pharmaceutical suppliers in UK

Medicines may be temporarily unavailable due to sudden and unexpected shortages in the market. Wholesale pharmaceutical suppliers UK provide the right medicines without delay. The service assures regular, uninterrupted supply of drugs that are unavoidable in clinical experiments and personal lives. The suppliers have close associations with chemists, pharmacists, multi-specialty hospitals and reputed medical practitioners spread all over the United Kingdom. Wholesale pharmaceutical suppliers in UK ensure that all customers are given satisfactory services through the well-organised supply-chain network. The distribution network all over UK is licensed by UK Medicines and Healthcare products Regulatory Agency (MHRA). The products are transported through sea, air or road and delivered on time in a cost-effective manner.

Why should I buy the products from wholesale pharmaceutical distributors?

If you want to buy pharmaceutical supplies in bulk, you can look for wholesale distributors online. Retailers and suppliers can buy the products from wholesale pharmaceutical distributors online or offline depending upon the requirements and budget. You can choose to buy the supplies online as you can save a lot of time, money, and efforts. Most of the wholesale distributors purchase the products directly from manufacturers. They do not have big showrooms and so the maintenance costs are low. They can afford to sell the pharmaceutical supplies at low rates. Hence, buying from reputed and trustworthy wholesale distributors is a good option.

There are many wholesale pharmaceutical distributors, who have operations in all the major cities. When you choose to buy pharmaceutical supplies online, you can make significant savings as they offer huge discounts and free shipping on some orders. Before choosing wholesale pharmaceutical distributors, you should do some research and find out whether the company is reliable or not.

Here are some tips to help you buy the right products at reasonable prices:

• Most of the distributors sell the products at great discounts when the customers buy in bulk. For example: If you have a requirement for a particular item on a regular basis, you can choose to buy it in bulk. Bulk orders can help you save a lot of money.
• One should ensure that the distributor is certified and licensed by the appropriate authorities.
• Wholesale pharmaceutical distributors may not allow walk-ins. If you are a walk-in customer, you can visit retail stores and buy the products from there. You may not always be able to buy single pieces from wholesaling companies. Check the terms and conditions before buying wholesale pharmaceutical supplies.
• Distributors do not need to maintain a showroom and so, the overhead costs are low. They save money and efforts on manpower, and other expenses. Hence, they sell the pharmaceutical supplies at low rates.
• Buy the supplies from wholesalers that provide free transportation for retailers.
• Find out what kind of customer service is provided by the wholesale pharmaceutical companies. You may need to communicate with them for transactions more frequently. Hence, determine the type of customer service they provide.

No matter what your requirements may be, make sure that you buy the products from reliable sources only. Compare the prices and other factors to find the right distributor. You may have to do some research online to get the best deal for pharmaceutical supplies, but it is essential to get all the required information before purchasing the products.

Wholesale Pharmaceutical Distributors in UK

With the increase in percentage of medication consumption in UK, the wholesale pharmaceutical distributors industry has been increasing rapidly. The industry not only helps in providing the products directly to the consumers and practitioners, but also helps in collaborative measure of all practitioners and scientists in order to release the tested drugs directly to the consumer. Other than supplying chains, the distributions of the products are a common practice taken under consideration by the wholesalers. The wholesale pharmaceutical distributors support the employment data in medical industry in UK to a great extent. The consumers of wholesale pharmaceutical distributors enjoy the freedom of cost of the product, which ultimately leads to larger number of customers of wholesale pharmaceutical distributors (UK).

Wholesale pharmaceutical distributors along with scientists, regulators and health care professionals have practiced the innovation in order to announce new medicines and therapies, which will be easily accessible to the common patients. This type of innovation has been practiced in UK currently, resulting into great success and appreciation by every patient in UK. It not only helps building successful relations amongst the professionals, but also supports the patients to every level of comfort.

Wholesale pharmaceutical distributors are taking corporate responsibilities in order to operate under the ethics of UK government. Not only it is an effective measure but mandatory measure as well in order to seek better care for every patient. In addition to the same, the corporate responsibility ill also let the distributors understand and effectively respond on the needs to the consumer in medical industry.

The better investment in science have supported in improving the health outcomes of UK citizens and easy eradication of diseases resulting into wholesale pharmaceutical distributors providing easy access of medicines to the patients. The pharmaceutical distributors have been a trademark improvement to deliver medicines and vaccines for the betterment of patients’ health. Compared to the older times, there has been noticeable great advances that have helped patients to eradicate their diseases because of easy access of the medicines and other drugs by wholesale pharmaceutical distributors UK. Wholesale pharmaceutical distributors have taken responsibility to combine the usage of generic and brand name medicines to become a useful outcome for the patients. The complete research of generic medicines is also a common practice for wholesale pharmaceutical distributors before punching to their systems to be effective. 

Wholesale pharmaceutical distributors are recognized and approved by MHRA proving the regulatory and certification of medicines and other products being distributed by them. Nothing has changed for MHRA after Brexit, because of presence of excellent scientists and practitioners in UK, which indeed are the major factor deciding staff for European Medical Authority (EMA) as well.

Not all the medicines needs a prescription and is easily accessible by the wholesale pharmaceutical distributors. For the medicines, which are restricted under prescription can only be regulated by the wholesale pharmaceutical distributors as well under the presence of practitioner or health care advisor. Such services were not availed before, but recent innovations adopted by UK, the collaboration of distributors with doctors and health care advisor has made it possible. This is a real time advantage to all the patients and customers as they can avail prescriptions directly from the distributors as well.

The wholesale pharmaceutical distributors, hereby, are making immense progress in medical industry by easing the lives of patients. Also, they support the economy of UK by sharing the largest number of employment under medical industry. The stable scientists and health care advisors working under collaboration with wholesale pharmaceutical distributors are working in unique manner to provide a collaborative solution to the patients in UK.

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Defining the Code of Practice for Pharmaceutical Companies in UK

Pharmaceutical companies in UK play a significant role in the healthcare system because they provide medicine and other products that are used to provide better healthcare to the patients. In this regard, these companies have an obligation to operate in a professional, ethical and transparent manner to ensure that there is appropriate use of medicine and other pharmaceutical products. It is important to note that this obligation includes the pharmaceutical wholesalers and the organisations that use these products.

Good manufacturing and distribution practices are essential in the pharmaceutical industry. UK Pharmaceutical companies should observe good manufacturing processes. In this regard, a pharmaceutical manufacturing company should manufacture and maintain high-quality products. In addition, the company should ensure that they produce right drugs, which are appropriate for their intended use. Furthermore, the company should meet the marketing authorisation requirements (MA) and product specification guidelines.

After the manufacturing of pharmaceutical products, the manufacturer involves the distributors to deliver their products to the licensed retailers. Good code of ethics dictates that all pharmaceutical companies in UK involve ethical and professional, pharmaceutical distributors in order to make sure the products do not end up in the wrong hands. In this case, good distribution practice should go through a licensed supply chain. The wholesalers should transport and handle the products in a suitable manner. Most importantly, the distributors should have a wholesale dealer license.

Pharmaceutical companies in UK have an obligation to maintain high standards during the manufacturing process. They should make sure that they operate in a responsible and ethical manner. The companies have a right to promote their products to the health professionals but they should do so in moderation. It is important to offer accurate information on the appropriate use of the medicine. Transparency in the manufacturing and distribution process is essential in order to build and maintain confidence in the pharmaceutical industry.

Medicines and Healthcare products Regulatory Agency (MHRA) is responsible for regulating medicines and medical devices use in healthcare in UK. All pharmaceutical companies in UK should meet their regulations guidelines before they start distributing their pharmaceutical products. This governing body carries out constant inspections to ascertain if the manufacturing and distribution sites comply with the good manufacturing and distribution practices. MHRA is responsible for issuing manufacturing and wholesale dealer license after inspecting the manufacturing and distribution sites.

Notably, pharmaceutical companies in UK play a significant role in supplying products that are essential for healthcare provision in the country. Manufacturing companies require wholesale distributors to supply their products to the licensed product retailers. Both manufacturers and distributors should observe a professional and ethical code in their manufacturing and distribution processes. They should make sure that they maintain transparency in the chain of distribution in order to make sure high-quality products reach the intended market.

Tips on Your Pharmacy Wholesalers Search in UK

With the latest and widest pharmaceutical options available, it is equally important to choose well when it comes to searching for pharmacy wholesalers in UK. Here are a few tips to refine your shortlist and eventually acquire the wholesaler to fit your needs:

A Wide Array of Items in their Inventory

The medicine wholesaler you will choose will need to have a complete stock of pharmaceutical items and drugs. Your look up on pharmacy wholesalers in UK would not be an ideal if pharmacies will need for some days for the bulk of meds to arrive. With an ideal wholesaler, the stocks should be kept fresh, updated and well packaged to be transferred to corresponding pharmacy outlets.

An Involved Professional Your Pharmacy Wholesalers in UK Search

While wholesaler pharmacists work on a business-to-business level, it is also important to look into how they would individually deal with their buyers. If they have outlets, which also sell individual products, you know you have done an effective search on pharmacy wholesalers in UK when they can handle client queries with kindness and patience.

A pharmacy wholesaler must also thoroughly understand how each pharmacist would handle the products they distribute on an individual level. For instance, they must understand how the medicines’ usage along with precaution measures will be relayed to the buyers.

An Understanding of Patient Involvement

The preferred wholesale pharmacist would know medicines are not mere goods, which need to be delivered on each pharmacy outlet. Each unit of the prescription drugs and other medicines will be actually taken by people to improve their health, and a wholesaler must cascade this quality of though in all levels. This is another important characteristic to look for when it comes to pharmacy wholesalers in UK.

This is why the ideal wholesaler would include more details on the packages of the medicines for more information on the end of the buyer. It would be understood how a pharmacist is not merely about to fill out prescriptions. A proactive one would recommend other medicines to support a chronic condition towards health improvement or perhaps suggest additional treatments should it be deemed for a patient to need one.

Pharmacy Wholesalers in UK, Which Work with Reputable Outlets

You will know a wholesaler is highly efficient and well trusted in the pharmacy distribution scene when it affiliates itself with very professional outlets. An ideal pharmacy would contact your provider on insurance should there be some issues to settle with. They would also speak with your doctor should there be additional queries on med refills. You have found an ideal supplier on pharmacy wholesalers in UK when they work with pharmacies with the mentioned qualities.

These are just few of the qualities you will need to look for among pharmacy wholesalers in UK. A reliable and trusty supplier will definitely be of help with your business especially in providing well for your customers.